Where do plasma cells produce antibodies?
Antibody-secreting cells develop in secondary lymphoid tissue following antigen stimulation and may enter a short-lived plasma cell population that reside primarily in the nonlymphoid area of the spleen or lymph nodes, or instead may migrate to the bone marrow where the majority enter a long-lived population of plasma ….
How many antibodies can a plasma cell produce?
Plasma cells can only produce a single kind of antibody in a single class of immunoglobulin. In other words, every B cell is specific to a single antigen, but each cell can produce several thousand matching antibodies per second. This prolific production of antibodies is an integral part of the humoral immune response.
What type of cells produce antibodies?
A lymphocyte is a type of white blood cell that is part of the immune system. There are two main types of lymphocytes: B cells and T cells. The B cells produce antibodies that are used to attack invading bacteria, viruses, and toxins.
Do plasma cells produce immunoglobulins?
Immunoglobulins are molecules produced by activated B cells and plasma cells in response to exposure to antigens. Upon antigen exposure, these molecules are secreted allowing the immune system to recognize and effectively respond to a myriad of pathogens.
Do T cells become plasma cells?
Cognate B cell / T cell interaction provides co-stimulation to B cells via CD40, which becomes activated on B cells via CD40 ligand (CD40L) expressed on T cells. T cells also provide cytokines to B cells that support their survival (IL-4), differentiation into plasma cells (IL-21) or class switch recombination.
What is the main function of plasma cells?
Plasma cells are differentiated B-lymphocyte white blood cells capable of secreting immunoglobulin, or antibody. These cells play a significant role in the adaptive immune response, namely, being the main cells responsible for humoral immunity.